Ohio State University and the Cleveland Clinic Foundation are Ohio's two largest transplant centers. OSU's kidney transplant program is among the highest-volume in the country.

Ohio State has an in-house Organ Assessment and Repair Center, that performs ex-vivo perfusion of kidneys and other organs, and has its own Organ Recovery Team to handle logistics for regional and national organ offers.

Ohio State may be particularly worth considering for highly sensitized patients. Patients with high cPRA are incompatible with a large proportion of potential donors, so finding the right kidney can remain difficult even though these patients receive substantial allocation priority. A very high-volume transplant program may provide an additional advantage: as more deceased-donor kidneys move through the program, patients are exposed to a more antigen-diverse set of kidneys, creating more opportunities for a donor whose HLA profile is compatible with a difficult-to-match recipient.

Ohio State's recent transplant volume appears particularly strong relative to its highly sensitized waiting-list demand. In 2024 and 2025, the program performed 101 deceased-donor kidney transplants in recipients with cPRA 80–100%, while its current waiting list includes only 58 candidates in this cPRA range. Highly sensitized candidates also represent a relatively small portion of the overall kidney waiting-list population, so the annual influx into these categories is much smaller than the program's total candidate volume.

OSU has strong living donor program. According to OPTN data, approximately one-third of its kidney transplants are living-donor transplants, and it has built a substantial paired-exchange operation. In December 2024 it completed a 10-way kidney exchange involving 10 donors and 10 recipients, one of the largest single-institution chains in the country.